Appendix 1 "Acceptable intakes established for N-nitrosamines" was prepared by the "Non-clincal Working Party (NcWP)" and the information provided there for the acceptable intakes (AIs) is based on the "Carcinogenic Potency Categorization Approach (CPCA)". In May 2024, new substances were added to Appendix 1, which consists of a tabular list of substances, and some existing entries in the list were updated. Sixteen substances were added and are marked in red and clearly recognizable in the list of acceptable intakes (AIs). These include:
2-(4-nitrosopiperazin-1-yl)ethanol
3-((ethyl(nitroso)amino)methyl) benzenesulfonate
4-nitroso-methyl piperazine-1-carboxylate
N-(2-hydroxy-2-phenylethyl)-N-(4-nitrophenethyl)nitrous amide
N-(4-aminophenethyl)-N-(2-hydroxy-2-phenylethyl)nitrous amide
N-nitroso-articaine
N-nitroso-desmethyl-edoxaban
N-nitroso-fenfluramine
N-nitroso-furosemide
N-nitroso-N-desmethyl-dextromethorphan
N-nitroso-posaconazole Impurity 1
Rivaroxaban Nitroso Impurity 1
Rivaroxaban Nitroso Impurity 2
Rivaroxaban Nitroso Impurity 5
N-nitroso-trientine Impurity 1
N-nitroso-vibegron
The entries for the substances "N-nitroso-folic acid" and "N-nitroso-lisinopril" have been updated.
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